Is brain banking of psychiatric cases valuable for neurobiological research? Using RNA-FISH, we demonstrate for the first time that Z inactivation plays a role in chicken dosage compensation, and confirmed that inactivation is also a feature of orthologous platypus X loci, as was previously shown by Deakin et al.
In this review, we will highlight four common medical issues in this population and how they might impact brain development. J Clin Exp Neuropsychol. Ann Hum Genet. Cardiovascular malformations are common in individuals with TS. Author information Article notes Copyright and License information Disclaimer.
However, GeneProb does not account for sex chromosome inheritance. See also: Sexual differentiation in humans. Nature Genet 6, — The performance of the algorithm was evaluated using genotype data on chromosome Z in a commercial chicken population and this was compared to the imputation of genotypes for autosomal chromosomes in the same population.
If a sperm cell containing an X chromosome fertilizes an egg, the resulting zygote will be XX, or female.
World J Biol Psychiatry. Identification of BAC Gene Content Genes were chosen based on three criteria: 1 Widespread expression in other species to maximize the chance they were expressed in platypus and chicken fibroblast cells.
Published online Jul Cutter et al. Journal List J Neurodev Disord v. For chicken expression data was available for brain, cerebellum, heart, kidney and liver. Significance remained after Bonferroni correction for all BACs.
Three of the four domains studied did not differ between the groups. The inconsistency in findings with this study may be due to the different tissue types used, and different inactivation profiles of chicken Z genes in other tissue types would not be surprising. With this realization comes a need for a better understanding of brain structure and function in individuals with TS.
The genetic basis for sex differences in human behaviour: role of the sex chromosomes.